Phosphorus dendrimers

BIODENDRIMERSDendrimers are a unique class of spherical, highly functionalizable macromolecules with perfectly defined structure. Dendrimer are composed of a core, branching points and surface functions.

The interior of the dendrimer offer cavities that can readily accept small molecules or particles, which make them ideally suited for encapsulation, isolation from external media or active catalytic sites. The surface of the dendrimer can be modified with a wide variety of function, allowing to finely tune the chemical, physical and topological properties of the molecule.

Phosphorus-based dendrimer is a unique family of dendrimer, which use a tetravalent thiophosphoryl trichloride as branching point and aromatic rings as repeating unit, which makes it easy to monitor via UVBIODENDRIMERS or 31P NMR spectroscopies. Dendrimer Advanced Technology offers 4 types of phosphorus dendrimers, varying the core or the surface functions

The 2 type of core are thiophosphoryl trichloride and hexachloro cyclotriphosphazene. Cyclotriphosphazene core dendrimers are spherical molecule, exhibiting 6 surface functions at the lowest generation, this number doubling each generation. Thiophosphoryl Chloride core dendrimers are wedge shaped dendrimers. The lesser hindered core allow for the preparation of higher generation dendrimers (up to 10).

Most dendrimers are soluble in dichloromethane, acetone, chloroform, THF, DMSO. They are insoluble in alcane (pentane), diethyl ether, alcohol.

Specificity of the phosphorus dendrimers

– Globular or Wedge shaped

N3P3Cl6 is a near flat molecule with 3 chlorine spamming one side of the ring et 3 in the other. This give the DNP dendrimers type a globular shape, hence offering at higher generation a complete 360° protection of the interior cavities.

PSCl3 leads on the other hand to wedge shaped dendrimers.

– Rigid scaffold due to the multiple double bond and aromatic rings forming the backbone

When deposited on a surface, phosphorus dendrimers do flatten to an oval shape but don’t collapse entirely, offering still cavities if needed.

– Hydrophobic interior with well defined cavity

The interior of the dendrimers is mainly hydrophobic. It potentially offers p interaction with aromatic ring, hydrogen bonding through the hydrazide function and dipolar interaction through the thiophosphoryl group. Customization of cavities interactions through variation of the branching unit can be studied.

– Highly versatile surface function

Basic phosphorus dendrimers are having either aldehyde or phosphoryl chloride surface functions. These are highly reactive functions that have been utilized in the past decade for the synthesis of hundreds dendrimers derivatives in the Majoral/Caminade research group. We provide our 15 years plus experience in dealing with this dendrimers to achieve the exact solution you are looking for.

– High thermal stability

– Reasonably stable in acidic media

– Can be monitored by UV, 31P  NMR,